Sinkers are used during a dissolution test to sink a dosage form that would otherwise float. The USP specifies that a small piece of non-reactive material, such as not more than a few turns of steel wire, can be attached to the dosage form to prevent floating. Other validated sinkers may also be used for this this purpose.

The sinker should have minimal surface contact with the tablet as this can affect the dissolution rate. The sinker weight should be heavy enough to ensure that the tablet sinks at the bottom of the vessel and doesn't move for the duration of the test.
PTFE coated sinkers can be used where there may be a reaction between steel and the tablet or when test are done with sticky samples.

Dissolution Accessories has a wide choice of sinker sizes available, do not hesitate to contact us by mail: info@prosense.net or phone +31 (0)162 47 14 85, when you are not sure which sinker you can use for your application and dissolution tester.

Capsule size	Length		Diameter
	(inches)	(mm)	(inches)	(mm)
000	1.029	26.1	0.390	9.91
00E	1.012	25.7	0.336	8.53
00	0.917	23.3	0.336	8.53
0E	0.909	23.1	0.301	7.65
0	0.854	21.7	0.301	7.65
1	0.765	19.4	0.272	6.91
2	0.709	18.0	0.250	6.35
3	0.626	15.9	0.229	5.83
4	0.563	14.3	0.209	5.32
5	0.437	11.1	0.193	4.91